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In order to improve the forecast service of public weather index, taking 8677 cases of cardiocerebrovascular disease (CCVd) inpatients in Dandong for recent 17 years as samples, based on the analysis of the relationship between the number of CCVd inpatients and meteorological factors, the impact of sudden weather changes on the morbidity of CCVd inpatients from November to February is studied. The results show: (1) The number of cardiovascular diseases inpatients is positively correlated with the air pressure and wind speed, with the correlation coefficients being 0949 and 0933, respectively, and negatively correlated with monthly average temperature with the correlation coefficient being -0992, both passed the test of 001 significance level; the number of CCVd inpatients in winter is larger than that in summer. (2) The number of CCVd inpatients is positively correlated with meteorological conditions such as cold fronts, cyclones, coldair outbreaks and gales. The results of this study can be used as the scientific basis for public weather index forecast. When the weather conditions that are favorable to the high incidence of CCVds are predicted, the warning massages will be provided to the public in time through new media such as SMS, microblog, and WeChat, which will be beneficial to prevent and reduce the occurrence of CCVds and achieve good social benefits.